Advances on association between indoor air pollution and 8-hydroxydeoxyguanosine in human urine
10.11836/JEOM21315
- VernacularTitle:室内空气污染与人群尿8-羟基脱氧鸟苷相关性研究进展
- Author:
Jingang SHI
1
;
Miao HE
1
Author Information
1. .
- Publication Type:Review
- Keywords:
indoor air pollution;
8-hydroxydeoxyguanosine;
DNA oxidative damage;
health damage
- From:
Journal of Environmental and Occupational Medicine
2022;39(4):465-469
- CountryChina
- Language:Chinese
-
Abstract:
8-hydroxydeoxyguanosine (8-OHdG) in human urine is a marker reflecting oxidative stress and DNA oxidative damage. People spend 80%-90% of their life indoors; therefore, indoor air quality is directly related to human health. In this paper, the urinary 8-OHdG levels were presented in populations grouped by different demographic characteristics, lifestyle, occupational exposure, and health status, and elucidated indoor pollutants affecting human urinary 8-OHdG level, such as pollutants from outdoor sources, smoking, indoor combustion and cooking fumes, the chemicals in interior decoration materials, and building foundation soils. The article aims to provide a theoretical basis for predicting the impact of indoor air pollution on human health (DNA oxidative damage and related diseases) by measuring the concentration of 8-OHdG in human urine.