Advances on association between indoor air pollution and 8-hydroxydeoxyguanosine in human urine

VernacularTitle:室内空气污染与人群尿8-羟基脱氧鸟苷相关性研究进展
Author: Jingang SHI ¹ ; Miao HE ¹
Author Information

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Publication Type:Review
Keywords: indoor air pollution; 8-hydroxydeoxyguanosine; DNA oxidative damage; health damage
From: Journal of Environmental and Occupational Medicine 2022;39(4):465-469
CountryChina
Language:Chinese
Abstract: 8-hydroxydeoxyguanosine (8-OHdG) in human urine is a marker reflecting oxidative stress and DNA oxidative damage. People spend 80%-90% of their life indoors; therefore, indoor air quality is directly related to human health. In this paper, the urinary 8-OHdG levels were presented in populations grouped by different demographic characteristics, lifestyle, occupational exposure, and health status, and elucidated indoor pollutants affecting human urinary 8-OHdG level, such as pollutants from outdoor sources, smoking, indoor combustion and cooking fumes, the chemicals in interior decoration materials, and building foundation soils. The article aims to provide a theoretical basis for predicting the impact of indoor air pollution on human health (DNA oxidative damage and related diseases) by measuring the concentration of 8-OHdG in human urine.