Nurses are key players in the newborn screening (NBS) program. The inherited nature of the conditions included in the NBS panel means that nurses should be competent in integrating genetics in their practice. However, studies suggest inadequate preparation of nurses in incorporating genetics in their practice. This article aims to discuss how nurses can capitalize on existing population-based genetics programs such as newborn screening to enhance their clinical practice through genetics. An overview of the newborn screening program in the Philippines is provided as well as a discussion on the roles of nurses in genetics in the context of NBS, and a brief discussion of future directions of the Philippine newborn screening program and how this may impact nursing education and research.