Nursing science needs to adopt a paradigm that can be used to apply its knowledge. Notably, how nursing science is applied in nursing practice or education remains confusing. This article aims to discuss the pros and cons of the two ways to implement nursing science, that is, evidence-based practice (including translational research and research utilization) and intuitive nursing. Also, I differentiated evidence-based practice (EBP), translational research (TR), and research utilization (RU). I argued that EBP as the paradigm of choice will be the optimal strategy for the future of nursing science. Adopting EBP improves patient, organizational, and staffing outcomes. While basing clinical decisions on intuition alone may imperil patient's safety due to multiple cognitive biases inherent in our intellectual devices. Combining EBP, TR, RU, and intuitive nursing resulted in a model Consilience in Evidence-based Practice. Implications of the model for nursing practice, education, and research were also discussed.