Medicinal plants with antimalarial activities mediated via glycogen synthase kinase-3 beta (GSK3β) inhibition
https://doi.org/10.47665/tb.39.3.008
- Author:
Hassan, W.R.M.
1
,
2
;
Ali, A.H.
3
;
Basir, R.
4
;
Embi, N.
5
;
Sidek, H.M.
5
Author Information
1. School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia&
2. Human Genetic and Biochemistry, Research Nexus of UiTM (ReNeU), Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
3. Department of Chemical Sciences, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
4. Pharmacology Unit, Department of Human Anatomy, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor, Malaysia
5. School of Biosciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
- Publication Type:Journal Article
- Keywords:
Medicinal plants;
kaempferol;
curcumin;
antimalarial activities;
glycogen synthase kinase-3 beta
- From:Tropical Biomedicine
2022;39(No.3):384-393
- CountryMalaysia
- Language:English
-
Abstract:
Many of the therapeutic effects of plant extracts and bioactive compounds appear related to their
immunomodulatory effects and impact on the host immune system. The immune response is desirable
to mitigate established infections and, in the case of severe malaria, is a feasible approach to dealing
with the overwhelming cytokine response. Glycogen synthase kinase-3 (GSK3), a Ser/Thr kinase that
is a central regulator of the cytokine response, is a promising antimalarial drug target. In this review,
we discussed our ongoing research projects, which include assessing the antimalarial activities of
medicinal plants and their bioactive compounds, immunomodulatory activities mediated by GSK3, and
the potential inflammatory pathway involved in malarial infection.
- Full text:8.2022my1353.pdf
