Endometrial polyps are localized outgrowths of glands and stroma within the endometrium primarily caused by hyperestrogenism. They are common causes of abnormal uterine bleeding and infertility by altering the endometrial surface. Polyps may be small, large (measuring more than one centimeter), or giant (more than 4 centimeters in size). Large and giant polyps are very rare and prone to oncologic malformation, thus biopsy is recommended. Endometrial resection with biopsy is the gold standard of treatment, but could be difficult since giant endometrial polyps occupy the entire endometrial cavity resulting to morbidity and failure on hysteroscopy. Limited case reports and studies have used gonadotropin releasing hormone (GnRH) agonist as preoperative therapy to decrease polyp size prior to hysteroscopic resection. The aim of this case report is to discuss a rare case of giant endometrial polyp treated with neoadjuvant GnRH agonist prior to hysteroscopic resection, and to present the recent literature regarding giant endometrial polyps.