A Clinicopathological Study of Solid and Papillary Neoplasm of Pancreas.
10.12701/yujm.1998.15.1.36
- Author:
Joon Hyuk CHOI
1
;
Mi Jin GU
;
Hong Jin KIM
Author Information
1. Department of Pathology, College of Medicine, Yeungnam University, Taegu, Korea.
- Publication Type:Original Article
- Keywords:
Solid and papillary epithelial neoplasm of pancreas;
Immunohistochemistry;
Ultrastructure
- MeSH:
Estrogens;
Female;
Head;
Humans;
Immunohistochemistry;
Keratins;
Mitochondria;
Neoplasms, Glandular and Epithelial;
Pancreas*;
Receptors, Progesterone;
Stem Cells;
Synaptophysin;
Vimentin
- From:Yeungnam University Journal of Medicine
1998;15(1):36-46
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Solid and papillary epithelial neoplasm of pancreas is a rare tumor, usually affecting young women, and its histogenesis is still controversial. This study was performed to define the clinicopathologic features and cellular origin of this tumor. Eight female cases of solid and papillary epithelial neoplasm of pancreas were studied by analyzing the clinicopathologic findings and immunohistochemical and electron-microscopic findings. The age of eight cases ranged from 21 to 54 years (mean, 34 years). The tumors developed in the tail (4 cases), body-tail (2 cases), body (1 case) and head (1 case). The mean diameter of tumors was 9.3 cm (range, 5.5 to 13 cm). Tumors showed solid, cystic and hemorrhagic areas. Histologically, the tumor cells were uniformly round or polygonal in shape, and formed solid sheets and papillary pattern. On the immunohistochemical stain, 8 cases (100%) were immunoreactive for alpha1-antitrypsin, 7 cases (87.5%) for cytokeratin, 7 cases (87.5%) for progesterone receptor, 6 cases (75%) for vimentin, and 1 case (12.5%) for synaptophysin, respectively. None of them were immunoreactive for estrogen receptor. Electron microscopic examination showed many mitochondria, annulate lamellae and canaliculi-like gap. These findings suggest that solid and papillary epithelial tumor of pancreas possibly originates from totipotential stem cells.
