Variants near CETP, MTTP and BUD13-ZPR1-APOA5 may be nominally associated with poor statin response among Filipinos.

Lourdes Ella G Santos; Jr Jose B Nevado; Eva Maria C Cutiongco - de la Paz; Lauro L Abrahan IV; Aimee Yvonne Criselle L Aman; Elmer Jasper B Llanes; Jose Donato A Magno; Deborah Ignacia D Ona; Felix Eduardo R Punzalan; Paul Ferdinand M Reganit; Richard Henry P Tiongco II; Jaime Alfonso M Aherrera; Charlene F Agustin; Adrian John P Bejarin; Rody G Sy

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Variants near CETP, MTTP and BUD13-ZPR1-APOA5 may be nominally associated with poor statin response among Filipinos.

Author: Lourdes Ella G. Santos ¹ ; Jose B. Nevado, Jr. ² ; Eva Maria C. Cutiongco - de la Paz ^{1
,

3} ; Lauro L. Abrahan IV ¹ ; Aimee Yvonne Criselle L. Aman ^{2
,

3} ; Elmer Jasper B. Llanes ¹ ; Jose Donato A. Magno ¹ ; Deborah Ignacia D. Ona ¹ ; Felix Eduardo R. Punzalan ¹ ; Paul Ferdinand M. Reganit ¹ ; Richard Henry P. Tiongco II ¹ ; Jaime Alfonso M. Aherrera ¹ ; Charlene F. Agustin ¹ ; Adrian John P. Bejarin ^{2
,

3} ; Rody G. Sy ¹
Author Information

1. Department of Medicine, Philippine General Hospital, University of the Philippines Manila
2. Institute of Human Genetics, National Institutes of Health, University of the Philippines Manila
3. Philippine Genome Center, University of the Philippines Diliman, Quezon City
Publication Type:Journal Article
Keywords: Filipino; MTTP
MeSH: Lipids; Hydroxymethylglutaryl-CoA Reductase Inhibitors
From: Acta Medica Philippina 2022;56(10):23-31
CountryPhilippines
Language:English
Abstract:
Objective. Several studies showed that genetic factors affect responsiveness to statins among different populations. This study investigated the associations of candidate genetic variants with poor response to statins among Filipinos.
Methods. In this unmatched case-control study, dyslipidemic participants were grouped into statin responders and poor responders based on the degree of reduction in LDL-c from baseline. DNA from blood samples were genotyped and analyzed. The association of candidate variants with statin response was determined using chi-square and logistic regression analysis.
Results. We included 162 adults on statins (30 poor responders as cases, 132 good responders as controls). The following variants are nominally associated with poor response to statin among Filipinos at a per-comparison error rate of 0.05: rs173539 near CETP (OR=3.05, p=0.015), rs1800591 in MTTP (OR=3.07, p=0.021), and rs1558861 near the BUD13-ZPR1-APOA5 region (OR=5.08, p=0.004).
Conclusion. Genetic variants near CETP, MTTP and the BUD13-ZPR1-APOA5 region are associated with poor response to statins among Filipinos. Further study is recommended to test the external validity of the study in the general Filipino population.
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