Endogenous Neural Stem Cells in Spinal Cord Injury(review)

VernacularTitle:内源性神经干细胞与脊髓损伤的研究进展
Author: Zhengfeng ZHANG
Publication Type:Journal Article
Keywords: endogenous neural stem cells, spinal cord injury, differentiation, review
From: Chinese Journal of Rehabilitation Theory and Practice 2010;16(4):344-346
CountryChina
Language:Chinese
Abstract: Recent advances in endogenous neural stem cells have made regeneration-based therapies feasible as therapeutic strategies for spinal cord injuries. Endogenous neural stem cells of the intact adult spinal cord reside not only in the ependymal layer of the central canal but also in the parenchyma, followed by responses of the activation and migration in the injured spinal cord. The most endogenous neural stem cells differentiate scar forming astrocytes and myelin-forming oligodendrocytes, but not neurogenic neurons. Thus the knowledge in intrinsic program of endogenous neural stem cells differentiation is obviously difficult and crucial for the recovery of spinal cord injury in the present.