Expression of APC-Cdh1 Protein after Cerebral Ischemia-reperfusion Damage in Rats
- VernacularTitle:大鼠全脑缺血-再灌注损伤后APC-Cdh1蛋白的表达
- Author:
Zhize CHEN
;
Li WAN
;
Yuehong QI
;
Wenlong YAO
;
Jin QIU
;
Chuanhan ZHANG
- Publication Type:Journal Article
- Keywords:
brain ischemia, hippocampus, anaphase promoting complex
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(4):339-341
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the expression of APC-Cdh1 protein after cerebral ischemia-reperfusion injury.Methods60 male Sprague-Dawley rats were randomly divided into Sham-operated group(SH) and ischemia-reperfusion group(IR). The rats of ischemia-reperfusion groups were induced by four-vessel occlusion (4-VO). At different times after injury, the expression of APC-Cdh1 of rat hippocampus was observed by Western blotting and immunohistochemistry.ResultsCompared with sham-operated group, the expression of Cdh1 protein significantly decreased 1 day and increased obviously 3 days, but decreased again 7 days after injury in ischemia-reperfusion group. The immuno-staining showed that APC-Cdh1 was highly cerebral cortex and hippocampus in ischemia-reperfusion group. ConclusionAPC-Cdh1 may be involved in the central nervous system injury.
