Arsenicosis presenting with cutaneous squamous cell carcinoma: A case report.

Author: Marie Len A. CAMACLANG ¹ ; Eileen Liesl A. CUBILLAN ² ; Claudine YAP-SILVA ²
Author Information

1. Section of Dermatology, Department of Medicine, Philippine General Hospital, University of the Philippines Manila
2. Section of Dermatology, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila
Publication Type:Journal Article
Keywords: Skin Cancer; Arsenicosis
MeSH: Arsenic; Arsenic Poisoning; Carcinoma, Squamous Cell; Carcinoma In Situ
From: Acta Medica Philippina 2019;53(2):171-176
CountryPhilippines
Language:English
Abstract: A 29-year-old male with eleven-year history of hyperkeratotic papules and speckled pigmentation developed cutaneous squamous cell carcinoma. Arsenicosis was confirmed by elevated hair arsenic level, and histopathologic findings of arsenical keratosis and one lesion showing carcinoma-in-situ. Chronic arsenic exposure has been found to activate inflammatory and carcinogenic pathways leading to development of pre-malignant and malignant lesions. A multi-disciplinary approach involving healthcare specialists and environmentalists is crucial in source control and management of long-term complications.
Full text:208-Article Text-811-2-10-20191030.pdf