Research progress on material basis for neurotoxicity of traditional Chinese medicine and its mechanism
- VernacularTitle:中药致神经毒性的物质基础与作用机制研究进展
- Author:
Hai HE
1
;
Shasha ZHAO
1
;
Yaoying XING
1
;
Ziyang WANG
1
;
Lidong DU
1
,
2
,
3
;
Jing SHAO
1
,
2
Author Information
1. College of Pharmacy，Gansu University of Chinese Medicine，Lanzhou 730000，China
2. Northwest Collaborative Innovation Center for Traditional Chinese Medicine and Tibetan Medicine Co-constructed by Gansu Province & MOE of PRC，Lanzhou 730000，China
3. Gansu Key Laboratory of Pharmacology and Toxicology of Traditional Chinese Medicine，Lanzhou 730000，China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
neurotoxicity;
material basis;
mechanism of action;
target;
toxic component
- From:
China Pharmacy
2023;34(2):251-256
- CountryChina
- Language:Chinese
-
Abstract:
In recent years， neurotoxicity caused by traditional Chinese medicine （TCM） has frequently occurred and has become one of the important factors restricting the development and application of TCM. TCM contains active components and its dosage-effect relationship is the key to determine its pharmacological activity and toxic effects. Among them， the endogenous toxic components include alkaloids， glycosides， diterpenoids， animal and plant toxic proteins and heavy metals， and so on； exogenous toxic components mainly refer to some harmful elements and pesticide residues during the cultivation， processing， transportation and storage of medicinal materials that are not synthesized by themselves. Effect on the processes such as oxidative stress， inflammation， ion exchange， and energy metabolism may be important mechanisms of TCM-induced neurotoxicity. Neural cells， myelin cells， axons and neurotransmitter systems are common targets of TCM-induced neurotoxicity. In the future， we can use modern research methods and big data mining means to establish a safety evaluation mode of “toxic symptoms-poisoning dose-toxic original agent-detoxification scheme” with the basic component group of toxic substances as the core， so as to provide support for development and clinical intervention of neurotoxic traditional Chinese medicine.
