Research progress of artemisinin and its derivatives in prevention and treatment of cardiovascular diseases
- VernacularTitle:青蒿素及其衍生物防治心血管疾病的研究进展
- Author:
Wenkuan LUO
1
;
Jianqi LU
2
;
Wenpeng CHEN
3
;
Yan PANG
2
;
Chaoxin PAN
2
;
Zhihao WEN
2
Author Information
1. Graduate School，Guangxi University of Chinese Medicine，Nanning 530001，China
2. Dept. of Cardiology，the First Affiliated Hospital of Guangxi University of Chinese Medicine/Branch Center，National Clinical Medical Research Center of Traditional Chinese Medicine for Cardiovascular Disease，Nanning 530022，China
3. Dept. of Neurocardiology，the Second Affiliated Hospital of Yunnan University of Chinese Medicine，Kunming 650215，China
- Publication Type:Journal Article
- Keywords:
artemisinin;
derivatives;
cardiovascular disease;
pharmacological effect
- From:
China Pharmacy
2023;34(2):246-250
- CountryChina
- Language:Chinese
-
Abstract:
Artemisinin is a sesquiterpene lactone containing a peroxide group isolated from the plant Artemisia annua. It has antimalarial activity and is effective for the treatment of malaria. With the deepening of research on artemisinin， the pharmacological effects of artemisinin and its derivatives in other systems have gradually become a research hotspot. This article reviews the research progress of artemisinin and its derivatives in the prevention and treatment of cardiovascular diseases. Artemisinin and its derivatives in the prevention and treatment of cardiovascular disease have shown anti-atherosclerosis， lipid- lowering， inhibition of vascular remodeling， reducing vascular pressure， improving ventricular remodeling， anti-arrhythmia， protection of vascular endothelium， prevention and treatment of diabetic cardiovascular complications and protection of myocardial cells and other pharmacological effects. It provides a new treatment strategy for common cardiovascular diseases such as hypertension， arrhythmia， coronary heart disease complications after stent implantation， hyperlipidemia， etc. However， there are few studies on the antiplatelet aggregation and antithrombotic effects of artemisinin and its derivatives， the molecular mechanisms behind many pharmacological effects have not yet been clarified， and there is little clinical application. A large number of basic studies and clinical trials are still needed to answer these questions.
