Relationship between ANKK1 gene polymorphism and atypical antipsychotic drug-induced metabolic syndrome
- VernacularTitle:ANKK1基因多态性与非典型抗精神病药物诱导的代谢综合征的相关性研究
- Author:
Renhua MIAO
1
;
Meng LI
1
;
Yanan WANG
1
;
Xingxing ZHUANG
1
Author Information
1. Dept. of Pharmacy，Chaohu Hospital of Anhui Medical University，Anhui Chaohu 238000，China
- Publication Type:Journal Article
- Keywords:
ANKK1;
metabolic syndrome;
gene polymorphism;
schizophrenia;
atypical antipsychotics
- From:
China Pharmacy
2023;34(2):195-199
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the relationship between the ANKK1 rs1800497 polymorphism and atypical antipsychotic drug-induced metabolic syndrome （MS）. METHODS Totally 94 patients with schizophrenia were included， and ANKK1 rs1800497 genotypes of patients were detected by micro-fluorescence immunoassay； social demographic information， clinical characteristics and other data were collected. The χ2 test was used to compare the correlation between the sex of patients and the occurrence of MS， and the correlation between gene polymorphism and the occurrence of MS and its risk factors.RESULTS Totally 94 patients included 24 cases （25.53%） of GG， 51 cases （54.26%） of GA and 19 cases of AA （20.21%）. Among them， there were 45 cases （47.87%） of MS， and the incidence of MS in male was higher than that in female （P＜0.05）. Genotype analysis showed that ANKK1 rs1800497 polymorphism was not associated with MS （P＝0.452）. ANKK1 rs1800497 A allele was significantly associated with hyperglycemia （χ2＝4.379， P＝0.036）， while it was not related to abdominal obesity， hypertension， high level of TG and low level of HDL-C （P＞0.05）， suggesting that for patients with schizophrenia， allele A was a relative risk factor for inducing hyperglycemia [OR＝2.008，95%CI（1.039， 3.881）]. CONCLUSIONS ANKK1 rs1800497 polymorphism has no correlation with the induction of MS by atypical antipsychotics， while the schizophrenia patients with A allele are more likely to induce hyperglycemia. The incidence of MS in male patients is significantly higher than that in female patients.
