The clinicopathological relevance of Poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer.
- Author:
Su Il SHIN
1
;
Hye In CHONG
;
Jeong Tae KIM
;
Dong Soo SUH
;
Man Soo YOON
;
Kyung Un CHOI
;
Chang Hun LEE
Author Information
1. Department of Obstetrics and Gynecology, College of Medicine, Pusan National University, Busan, Korea. msyoon@webmail.pusan.ac.kr
- Publication Type:Original Article
- Keywords:
PARP;
Epithelial ovarian cancer
- MeSH:
Mitosis;
Ovarian Neoplasms*;
Retrospective Studies
- From:Korean Journal of Obstetrics and Gynecology
2007;50(8):1100-1106
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: To evaluate the clinicopathological implication of poly (ADP-ribose) polymerase (PARP) expression in epithelial ovarian cancer. METHODS: Retrospectively, slide samples (n=72) were analyzed. PARP expression was analyzed using immunohistochemical staining. RESULTS: Of 72 cases, positive PARP expression were 27 cases (37.5%). PARP expression showed negative correlation with FIGO stage (p=0.004) and mitotic count (p=0.010), but showed no correlation with grade (p=0.053), tumor size (p=0.301), Ki-67 LIs (p=0.986), p53 positivity (p=0.414), and bcl-2 positivity (p=0.413). CONCLUSION: PARP expression showed negative correlation with advanced stage and mitoses in epithelial ovarian cancer. Therefore PARP expression could be a new prognostic factor in epithelial ovarian cancer.
