Role of Ammonia in the Pathogenesis of Hepatic Encephalopathy (review)
- VernacularTitle:氨在肝性脑病发病机制中的作用
- Author:
Qingjun ZHANG
;
Yanyong LIU
;
He LIU
;
Pingping ZUO
- Publication Type:Journal Article
- Keywords:
encephalopathy (HE), ammonia toxicity, oxidative stress, energy metabolism, mitochondrion, review
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(2):136-139
- CountryChina
- Language:Chinese
-
Abstract:
Ammonia toxicity has been generally accepted as one of the classic theories of the pathogenesis of hepatic encephalopathy (HE). Ammonia induces changes in neurological system energy metabolism, oxidative stress, mitochondrial permeability transition (MPT), GABA and Glutamatergic neurotransmission, intracellular signal transduction and Aquaporin 4 (AQP4) expression, astrocyte swelling is another important consequence of ammonia neurotoxicity. This article reviewed the role of these factors in the mechanism of HE and ammonia toxicity.
