Chiral separation of four acidic drugs by micellar electrokinetic chromatography with ionic liquid-based surfactant
10.11665/j.issn.1000-5048.20220610
- VernacularTitle:离子液体型表面活性剂的胶束电动色谱法手性拆分4种酸性药物
- Author:
Ke YANG
1
;
Tao YU
Author Information
1. 中国药科大学理学院
- Publication Type:Journal Article
- Keywords:
capillary electrophoresis;
ionic liquid;
micellar electrokinetic chromatography;
surfactant;
chiral separation;
acidic drugs
- From:
Journal of China Pharmaceutical University
2022;53(6):710-715
- CountryChina
- Language:Chinese
-
Abstract:
In this paper, micellar electrokinetic chromatography (MEKC) with glucose-β-cyclodextrin (Glu-β-CD) as chiral selector and ionic liquid surfactant N-butyl-N-methyl pyrrolidine lauryl sulfate ([C4MP] [C12SO4]) micelles formed at low pH as a pseudo stationary phase was applied for the chiral separation of four acidic drugs naproxen,warfarin, ketoprofen and ibuprofen.Under the same conditions,significantly improved separation of tested drug enantiomers was achieved with the MEKC system based on [C4MP][C12SO4] compared with the system based on the conventional surfactant sodium dodecyl sulfate (SDS).Several primary parameters affecting enantioseparation such as type and proportion of organic modifier, concentration and pH of the running buffer, concentration of chiral selector,concentration of ionic liquid surfactant and applied voltage were systematically investigated.
