Research progress of N6-methyladenine demethylase inhibitors
10.11665/j.issn.1000-5048.20220604
- VernacularTitle:N6-甲基腺嘌呤去甲基化酶抑制剂研究进展
- Author:
Jing GAO
1
;
Xue MI
;
Qi ZHOU
;
Jun ZHOU
Author Information
1. 中国药科大学生命科学与技术学院
- Publication Type:Journal Article
- Keywords:
N6-methyladenosine (m6A);
demethylase;
fat mass and obesity-associated protein;
AlkB homlog 5;
enzyme inhibitors;
progress
- From:
Journal of China Pharmaceutical University
2022;53(6):663-673
- CountryChina
- Language:Chinese
-
Abstract:
N6-methyladenine (m6A) modification, the most abundant and dynamic chemical modification on messenger RNA, plays an essential role in physiological and pathological progress.Recent studies have found that tumor progression can be affected by altering the m6A modification level of target genes. Therefore, small molecule targeted m6A demethylase can be used as a new anti-tumor strategy.This review focuses on the regulatory mechanism of m6A demethylases, including fat mass and obesity-associated protein (FTO) and AlkB homlog 5 (ALKBH5), as well as their biological functions in tumors, and summarizes the research progress of their small molecule inhibitors.
