Research progress of nasal mucosal immunization vaccine against COVID-19
10.11665/j.issn.1000-5048.20220602
- VernacularTitle:COVID-19鼻腔黏膜免疫疫苗的研究进展
- Author:
Yaqi WU
1
;
Meng LI
;
Haonan XING
;
Daquan CHEN
;
Aiping ZHENG
Author Information
1. 烟台大学药学院
- Publication Type:Journal Article
- Keywords:
COVID-19;
SARS-CoV-2;
respiratory infection;
nasal mucosal immune vaccine;
triple immunity
- From:
Journal of China Pharmaceutical University
2022;53(6):643-650
- CountryChina
- Language:Chinese
-
Abstract:
Respiratory mucosal immune system is the body''s first line of defense against infection.Since the outbreak of novel coronavirus disease 2019 (COVID-19) in 2019,nasal mucosal immune vaccine, with its ability to induce cellular, humoral and mucosal triple immune responses, has become a research hotspot.This article focuses on novel coronavirus, with an understanding of its structure and pathogenesis, a brief introduction to the immune mechanism of nasal mucosa, a summary of the different types of nasal mucosal immune vaccines and their clinical research, aiming to provide some theoretical reference for the development of new vaccines, and exploration of the best methods and strategies to combat COVID-19.
