Effects of Local Mild Hypothermia on Dopamine and 5-Hydroxytryptamine in Basal Ganglion of Neonatal Rabbits with Bilirubin Encephalopathy
- VernacularTitle:局部亚低温对胆红素脑病仔兔脑基底节中多巴胺及5-羟色胺的影响
- Author:
Limei WANG
;
Yanqiu HAO
;
Lihong SHI
- Publication Type:Journal Article
- Keywords:
bilirubin encephalopathy, mild hypothermia, dopamine, 5-hydroxytryptamine
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(1):35-37
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo observe the effects of local mild hypothermia at different time on dopamine (DA) and 5-hydroxytryptamine (5-HT) concentration in rabbits brain basal ganglion with bilirubin encephalopathy. MethodsThe model of bilirubin encephalopathy was established, and treated with mild hypothermia for different time. The DA and 5-HT in the basal ganglion were detected with fluorescence spectrophotometry. ResultsThe DA and the 5-HT decreased in the basal ganglion significantly after modeling (P<0.01), and increased when treated for 6 h, 12 h or 24 h (P<0.01). ConclusionLocal mild hypothermia can significantly reduce the disorder of DA and 5-HT during bilirubin encephalopathy. The longer the hypothermia, the better the effect is.
