Effects of Morroniside on Rats Neurons in Focal Cerebral Ischemia/Reperfusion Injury
- VernacularTitle:莫诺苷对局灶性脑缺血再灌注大鼠神经元损伤的影响
- Author:
Wen WANG
;
Dongming XU
;
Jie XIANG
;
Lei LI
;
Peichang WANG
;
Houxi AI
;
Li ZHANG
;
Lin LI
- Publication Type:Journal Article
- Keywords:
morroniside, ischemia/reperfusion, super oxide dismutase (SOD), neuroprotective
- From:
Chinese Journal of Rehabilitation Theory and Practice
2010;16(1):27-28
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the effects of morroniside on super oxide dismutase (SOD) and neurons in rats cortex with focal cerebral ischemia/reperfusion. MethodsThe animal model was induced by middle cerebral artery occlusion with suture embolus, cerebral ischemia 30 min and reperfusion 3 d or 7 d. Vitamin E for the positive control. The content of SOD was detected with spectrophotometry and the nerve cells was observed with immunohistochemistry. ResultsCompared with model group, morroniside （270 mg/kg）increased the activity of SOD and the number of neurons （30 mg/kg, 90 mg/kg, 270 mg/kg） significantly. ConclusionMorroniside may have neuroprotective effect and increasing the activity of SOD in rats cortex.
