Inflammatory and Anti-Inflammatory for Parkinson's Disease (review)

VernacularTitle:帕金森病的炎症及抗炎药物的研究进展
Author: Meirong ZHANG ; Fangling SUN ; Houxi AI ; Li ZHANG ; Ying JIANG ; Shourong WEI ; Wen WANG
Publication Type:Journal Article
Keywords: Parkinson's disease, microglia, inflammation, anti-inflammatory drug, review
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(11):1040-1043
CountryChina
Language:Chinese
Abstract: Parkinson's disease (PD) is one of the most prevalent neurodegenerative movement disorder in human being, characterized by progressive degeneration and lost of dopamine (DA)-producing neurons in the substantia nigra pars compacta (SNpc),causing low level of DA in the nigrostriatal pathway, eventually leading to motor dysfunctions including tremor, rigidity, bradykinesia,and postural instability.The pathology of PD is complex and the etiology remains poorly understood. In recent years,inflammation has been suggested to be involved in the occurrence and development of PD, by activation of microglia and overexpression of the inflammatory factors. And anti-inflammatory drugs has been developed to delay or prevent the progressive course of PD, becoming a new hotspot in treatment of PD. In this review, the latest progresses on the inflammatory mechanisms and anti-inflammatory treatments of PD was introduced.