Effect of Electroacupuncture Combined with Edaravone on Conduction Velocity of Sciatic Nerve and Oxidative Stress in Rats with Diabetic Peripheral Neuropathy
10.3969/j.issn.1006-9771.2012.11.013
- VernacularTitle:电针联合依达拉奉对糖尿病周围神经病大鼠坐骨神经传导速度和氧化应激的影响
- Author:
Youbo QIU
;
Shaohua XIE
;
Zheng YANG
;
Menglang YUAN
;
Yucheng LI
;
Mingli JIANG
;
Deqi CAO
;
Li XI
;
Xiao ZHANG
- Publication Type:Journal Article
- Keywords:
diabetic peripheral neuropathy, electroacupuncture, edaravone, oxidative stress, nerve conduction velocity
- From:
Chinese Journal of Rehabilitation Theory and Practice
2012;18(11):1036-1039
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of electroacupuncture combined with edaravone on the conduction velocity of sciatic nerve and oxidative stress in rats with diabetic peripheral neuropathy. Methods 60 Sprague Dawley (SD) rats were included. 10 of them were selected as normal group. The other rats were modeled as diabetic peripheral neuropathy with streptozotocin. 48 of them were randomly selected and divided into electroacupuncture group (n=12), edaravone group (n=12), electroacupuncture + edaravone group (n=12), and model group (n=12). The threshold temperature for wave tail was tested, the levels of superoxidase dismutase (SOD) and malonaldehyde (MDA) were determined, and the conduction velocity of sciatic nerve were measured, before, and 4 and 8 weeks after modeling. Results 8 weeks after modeling, the conduction velocity and SOD increased in the electroacupuncture group, edaravone group and electroacupuncture+edaravone group compared with the model group (P<0.01), with the MDA decrease (P<0.01), while it was improved more in the electroacupuncture+edaravone group than in the electroacupuncture group or the edaravone group (P<0.01). Conclusion Both electroacupuncture and edaravone can inhibit oxidative stress and improve nerve conduction velocity of the sciatic nerve in rats with diabetic peripheral neuropathy, and it is more effective of combination.
