Effect of Pleurotus Eryngii Polysaccharide on Learning and Memory Ability and Antioxidant of Aging Mice Induced by D-galactose

VernacularTitle:杏鲍菇多糖对衰老模型小鼠学习记忆能力和脑组织抗氧化能力的影响
Author: Bingwei YAO ; Zhengfeng GU ; Bo XU ; Dan LI ; WeI LIAN ; Wei SHENG
Publication Type:Journal Article
Keywords: aging, Pleurotus eryngii polysaccharide, D-galactose, mice
From: Chinese Journal of Rehabilitation Theory and Practice 2012;18(11):1033-1035
CountryChina
Language:Chinese
Abstract: Objective To study the effect of Pleurotus eryngii polysaccharide on aging mice induced by D-galactose (D-gal). Methods 72 ICR mice were divided into high, moderate, and low dosages (of polysaccharide) groups, piracetam group, model group, and control group, 12 in each group. The model of aging mice was induced with D-gal. They were tested with Y-maze, and the contents of superoxide dismutase (SOD), malondialdehyde (MDA), lipofuscin and L-glutamate in cerebrum were determined 6 weeks after model. Results Compared with the model group, the achievement of Y-maze improved, the activities of SOD increased and the content of MDA and lipofuscin decreasd in high and moderate dosage groups (P<0.05), while the mass of brain and kidney increased and the L-glutamate decreased in the high dosage group (P<0.05). Conclusion Pleurotus eryngii polysaccharide can ameliorate aging of mice induced by D-gal.