Effect of Body Weight Support Treadmill Training or Du Channel Electroacupuncture on Expressions of Nerve Growth Factor and Growth-associated Protein-43 in Rats with Spinal Cord Transection
10.3969/j.issn.1006-9771.2012.10.010
- VernacularTitle:减重步行训练和督脉电针对脊髓损伤大鼠神经营养因子及生长相关蛋白-43 表达的影响
- Author:
Huilan LI
;
Lanqun LIU
;
Huying LU
;
Zhiheng CHEN
;
Jimin XU
;
Honglei CHEN
- Publication Type:Journal Article
- Keywords:
body weight support treadmill training, Du channel electroacupuncture, spinal cord injury, nerve growth factor, growth-associated protein-43
- From:
Chinese Journal of Rehabilitation Theory and Practice
2012;18(10):930-933
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of body weight support treadmill training (BWSTT) or Du channel electroacupuncture (DcEA) on locomotion function and expressions of nerve growth factor (NGF) and growth-associated protein-43 (GAP-43) in rats with spinal cord transection. Methods 54 adult SD rats were divided into control group (n=18), BWSTT group (n=18) and DcEA group (n=18). Each group was divided into 3 subgroups (n=6) for 8 d, 15 d and 30 d respectively. Spinal cord transection was performed at T10 level. The locomotion function was assessed with Bosso-Beattie-Bresnahan locomotor rating scale for open field (BBB scale) and the expressions of NGF and GAP-43 in spinal cord tissues to the injury caudal ends were measured with immunohistochemistry. Results The scores of BBB scales and expressions of NGF and GAP-43 were higher in BWSTT group and DcEA group than those in the control group on the 8th d,15th d and 30th d respectively (P<0.01); and were higher in DcEA group than in BWSTT group on the 15th d and 30th d respectively (P<0.01). Conclusion Both BWSTT and DcEA can improve the locomotion function in rats with spinal cord transection and increase expressions of NGF and GAP-43 in spinal cord tissues, and DcEA is more effective.
