Research progress on anhepatic phase in rat liver transplantation
10.3969/j.issn.1674-7445.2023.01.019
- VernacularTitle:大鼠肝移植无肝期研究进展
- Author:
Tian HAN
1
;
Li ZHANG
;
Qingyao CHANG
;
Xiang LI
;
Xiaopeng HE
;
Zhening YAN
;
Lin GAO
;
Jun XU
Author Information
1. Department of Hepatobiliary and Pancreatic Surgery, Liver Transplantation Center, the First Hospital of Shanxi Medical University, Taiyuan 030001, China
- Publication Type:Research Article
- Keywords:
Rat;
Liver transplantation;
Anhepatic phase;
Inferior vena cava;
Portal vein;
Fluid infusion;
Magnetic ring anastomosis;
Stent anastomosis;
Cannula anastomosis
- From:
Organ Transplantation
2023;14(1):142-
- CountryChina
- Language:Chinese
-
Abstract:
With persistent advancement of surgical instruments, methods and techniques, clinical efficacy of liver transplantation has been steadily enhanced. However, the length of anhepatic phase is still an important factor affecting the efficacy of liver transplantation. Rat is one of the major animal models for liver transplantation-related basic research. In this article, multiple approaches for prolonging the anhepatic phase and shortening the operation time during anhepatic phase in rat liver transplantation were reviewed, which consisted of sevoflurane inhalation anesthesia, intravenous infusion via jugular vein indwelling needle, clamping of the abdominal aorta before anhepatic phase, injection of normal saline into portal vein before anhepatic phase, subcutaneous transposition of the spleen, electrocoagulation of hepatic esophageal artery, magnetic ring anastomosis of the superior and inferior hepatic vena cava, cannula anastomosis of the superior and inferior hepatic vena cava, stent anastomosis of the superior and inferior hepatic vena cava, rapid connection device and cannula of portal vein, and ring-shaped cannula of hepatic tissue-preserving inferior hepatic vena cava, aiming to add evidence for prolonging the duration of anhepatic phase, improving the operation efficiency during anhepatic phase and elevating the success rate of rat liver transplantation.
