Development status and new challenges of heart transplantation
10.3969/j.issn.1674-7445.2023.01.004
- VernacularTitle:心脏移植的发展现状和新挑战
- Author:
Liangwan CHEN
1
;
Qianzhen LI
;
Xiaofu DAI
;
Guanhua FANG
;
Zhihuang QIU
Author Information
1. Department of Cardiovascular Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China
- Publication Type:Research Article
- Keywords:
Heart transplantation;
Cardiac allograft vasculopathy (CAV);
Donation after cardiac death (DCD);
Donation after brain death (DBD);
Normothermic machine perfusion (NMP);
Extracorporeal membrane oxygenation (ECMO);
Static cold storage (SCS);
Primary graft dysfunction (PGD);
Donor-derived cell-free DNA (dd-cfDNA)
- From:
Organ Transplantation
2023;14(1):31-
- CountryChina
- Language:Chinese
-
Abstract:
Heart transplantation is the primary therapeutic option for patients with end-stage heart failure. The shortage of donors has been the main limiting factor for the increasing quantity of heart transplantation. With persistent updating and introduction of novel technologies, the donor pool has been increasingly expanded, such as using the heart from older donors, donors infected with hepatitis C virus, donors dying from drug overdose or donation after cardiac death (DCD) donors, etc. Meantime, the proportion of recipients with advanced age, multiple organ dysfunction, mechanical circulatory support and human leukocyte antigen antibody sensitization has been significantly increased in recent years. The shortage of donors, complication of recipients' conditions, individualized management of immunosuppressive therapy and prevention and treatment of long-term cardiac allograft vasculopathy are all challenges in the field of heart transplantation. In this article, novel progresses on donor pool expansion, improving the quality of recipients, strengthening the diagnosis and treatment of rejection, and preventing cardiac allograft vasculopathy were reviewed, aiming to prolong the survival and enhance the quality of life of patients with end-stage heart failure on the waiting list or underwent heart transplantation.
