Association between smoking and ankylosing spondylitis: a Mendelian randomization study
10.19485/j.cnki.issn2096-5087.2023.01.001
- Author:
Hong YANG
;
Wei LIU
;
Peiyang LUO
;
Jie SONG
;
Yuqing JIANG
;
Zhixing HE
;
Ding YE
;
Yingying MAO
- Publication Type:Journal Article
- Keywords:
smoking;
ankylosing spondylitis;
genetic variation;
Mendelian randomization
- From:
Journal of Preventive Medicine
2023;35(1):1-5
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the association of smoking with the risk of ankylosing spondylitis (AS) using a Mendelian randomization (MR) approach.
Methods:A total of 16 383 186 AS-associated single nucleotide polymorphisms (SNPs), 378 smoking initiation associated SNPs and 126 lifetime smoking score-associated SNPs were collected from three large-scale genome-wide association studies (GWAS). The association of smoking phenotypes with the risk of AS was examined using inverse-variance weighted (IVW) with AS as a outcome variable, smoking initiation and lifetime smoking score as exposure factors and SNPs with strong associations with smoking as instrumental variables, and sensitivity analyses were performed with maximum likelihood-based method, MR pleiotropy residual sum and outlier (MR-PRESSO) test and MR-Egger regression analysis.
Results: A 33.5% increased risk of AS was found among genetically predicted smokers relative to non-smokers (OR=1.335, 95%CI: 1.059-1.682), and an increase in predicted lifetime smoking by per standard deviation resulted in a 101.4% increased risk of AS (OR=2.014, 95%CI: 1.341-3.024). The maximum likelihood-based method and MR-PRESSO test showed consistent correlated effect estimations and MR-Egger regression analysis identified no evidence of pleiotropy.
Conclusion:It is genetically predicted that smoking is associated with an increased risk of AS.
- Full text:吸烟与强直性脊柱炎关联的孟德尔随机化研究.pdf
