Whey protein positively alters inflammatory markers and metabolic parameters of overweight and obese adults
https://doi.org/10.31246/mjn-2021-0100
- Author:
Chanchira Phosat
1
;
Charupan Phosat
2
;
Chatrapa Hudthagosol
1
;
Pornpimol Panprathip Phienluphon
3
;
Karunee Kwanbunjan
3
Author Information
1. Department of Nutrition, Faculty of Public Health, Mahidol University, Bangkok, Thailand
2. Faculty of Traditional Chinese Medicine, Huachiewchalermprakiet University, Samut Prakan, Thailand
3. Department of Tropical Nutrition and Food Science, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand
- Publication Type:Journal Article
- Keywords:
inflammatory marker, obesity, overweight, plant-based protein, whey protein
- From:
Malaysian Journal of Nutrition
2022;28(No.3):369-382
- CountryMalaysia
- Language:English
-
Abstract:
Introduction: The effects of prolonged consumption of whey protein on health
are controversial. This study aimed to determine whether whey protein positively
alters health parameters of overweight and obese adults. Methods: Randomised
controlled trial was conducted. Fifty-eight participants, aged 30-50 years, were
randomly allocated into four groups and supplemented with 50 g protein for eight
weeks (group 1: plant-based protein (PBP), group 2: whey protein isolate (WPI) with
cocoa powder, group 3: PBP with whey protein concentrate (WPC), and group 4: WPI
with milk powder). Body composition and biochemical parameters (kidney and liver
functions, inflammation, oxidative stress, and antioxidant capacity) were evaluated
at pre-intervention and 8 weeks after intervention. Results: At Week 8, group 3 had
lower diastolic blood pressure, waist circumference, visceral fat, and risk of insulin
resistance (p<0.05 for all). Group 2 had decreased levels of total cholesterol and
low-density lipoprotein cholesterol (p<0.05 for all). A drop in triglyceride was seen in
group 4 (p=0.026). Whey protein decreased alanine aminotransferase level (p=0.028),
while PBP increased aspartate aminotransferase level (p=0.034). PBP or WPI with
milk powder increased blood urea nitrogen level (p>0.05 for all). Interleukin-6 and
lactoferrin levels fell in all groups (p<0.05), while hs-CRP increased in the PBP
group (p=0.043). Group 2 experienced increased antioxidant capacity. However,
levels of oxidative stress markers were significantly decreased in the PBP group and
WPI with milk powder group. Conclusion: Whey protein revealed positive effects
on anthropometric parameters and biochemical markers of overweight and obese
adults. Therefore, proper supplementation of whey protein can potentially promote
health.
- Full text:4.2022my0591.pdf
