Progress of heat shock protein 47 in glioma
10.3760/cma.j.cn115355-20210727-00324
- VernacularTitle:热休克蛋白47在胶质瘤中的研究进展
- Author:
Zhuangzhuang WANG
1
;
Hubin DUAN
Author Information
1. 山西医科大学第一医院神经外科，太原 030001
- Keywords:
Heat shock protein 47;
Glioma;
Angiogenesis;
Immunotherapy;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2022;34(11):873-876
- CountryChina
- Language:Chinese
-
Abstract:
Heat shock protein 47 (HSP47) is mainly involved in regulating collagen folding, secretion and maturation in the tumor microenvironment (TME) and is widely amplified in human cancers. HSP47 has been shown to be overexpressed in a variety of extracranial tumors. In glioma, the expression of HSP47 correlates with the grading of glioma and is involved in proliferation, invasion, angiogenesis, and immune regulation of glioma, regulates the TME of glioma, and promotes the survival of glioma stem cells, which may be related to the heterogeneity of glioma. This article reviews the progress of HSP47 in the development and progression of glioma, and discusses the significances of HSP47 in the proliferation, invasion, targeted therapy and immunotherapy of glioma.
