Progress on the mechanism of chemokine CCL2 in the malignant progression of glioma

VernacularTitle:趋化因子CCL2在胶质瘤恶性进程中作用机制的研究进展
Author: Yijie NING ¹ ; Yiyi HU ; Yongquan CHEN ; Hubin DUAN ; Hongqin WANG
Author Information

1. 山西医科大学第一医院神经外科，太原　030001
Keywords: Glioma; Chemokine CCL2; Biomarker; Mechanism
From: Cancer Research and Clinic 2022;34(11):869-872
CountryChina
Language:Chinese
Abstract: Glioma is the most common primary intracranial tumor. At present, the conventional treatment methods have limited effect and cannot significantly prolong the survival time of patients. Chemokine CCL2 is the most important member of the CC chemokine family, which can regulate glioma angiogenesis, immunosuppression, progression and invasion, and resistance to apoptosis. This article reviews the potential mechanism of CCL2 promoting the malignant progression of glioma, in order to provide new ideas and methods for the targeted therapy of glioma.