Progress of tumor treating fields for glioma

VernacularTitle:肿瘤电场治疗在胶质瘤中的研究进展
Author: Zhuo LIU ¹ ; Xiaolin ZHU ; Wen XUE ; Hubin DUAN
Author Information

1. 山西医科大学附属吕梁医院神经外科，吕梁　033000
Keywords: Neoplasms; Photochemotherapy; Combined modality therapy
From: Cancer Research and Clinic 2022;34(10):786-789
CountryChina
Language:Chinese
Abstract: Glioma is a common primary malignant brain neoplasms which is characterized with easy recurrence and poor prognosis. The overall survival of glioma patients is not satisfying. Tumor treating fields (TTFields) is an emerging low-toxicity treatment for solid neoplasms, and its technical basis is to form an anti-tumor electric field in a specific area. TTFields can inhibit the proliferation of tumor cells through inhibiting cell mitosis, replicating stress, inducing autophagy and apoptosis, and inhibiting DNA damage and repair, and induce the cell death without affecting normal cells in the resting phase. At present, TTFields has been approved for various types of gliomas and is gradually becoming an effective treatment protocol for glioma following surgery, radiotherapy and chemoradiotherapy. Many preclinical and clinical studies have confirmed that TTFields inhibits glioma cells and significantly increases the overall survival rates of patients.This paper reviews the progress of related researches.