Progress of the pathogenesis in Merkel cell carcinoma
10.3760/cma.j.cn115355-20210423-00185
- VernacularTitle:默克尔细胞癌发病机制的研究进展
- Author:
Shaojun XUE
1
;
Mengyuan ZHANG
;
Ziguo WANG
;
Juntao ZHOU
;
Xianfeng LI
Author Information
1. 山西医科大学第一医院放疗科，太原 030001
- Keywords:
Neuroendocrine tumors;
Merkel cell;
Immunohistochemistry;
Research
- From:
Cancer Research and Clinic
2022;34(9):710-713
- CountryChina
- Language:Chinese
-
Abstract:
Merkel cell carcinoma (MCC) is a rare primary neuroendocrine carcinoma of the skin, which is named for its ultrastructure and immunophenotype similar to Merkel cells in the skin. It has been found that the integration of MCC with the oncogenic Merkel cell polyomavirus (MCPyV) may drive tumorigenesis or cause somatic mutations to the development of MCC because of ultraviolet ray-induced DNA damage. However, the pathogenesis of MCC is still unclear. This article introduces the current research progress of the pathogenesis of MCC, hoping to provide theoretical guidance for follow-up researches.
