The Effect of Itopride, a New Prokinetic, on Acid Reflux Symptoms and Variables in Patients with GERD.
- Author:
Suck Chei CHOI
1
;
Tae Hyeon KIM
;
Hee Sik KIM
;
Chong Ju IM
;
Kyo Sang YOO
;
Young Woo SOHN
;
Joo Jin YEOM
;
Yong Sung KIM
;
Sang Wook KIM
;
Geom Seog SEO
;
Yong Ho NAH
Author Information
1. Department of internal medicine, College of medicine, Wonkwang University, Iksan, Korea. medcsc@wmc.wonkwang.ac.kr
- Publication Type:Original Article ; Randomized Controlled Trial
- Keywords:
Gastroesophageal reflux disease;
Itopride
- MeSH:
Appointments and Schedules;
Endoscopy;
Esophagitis;
Gastroesophageal Reflux*;
Humans;
Hydrogen-Ion Concentration;
Random Allocation;
Symptom Assessment
- From:Korean Journal of Gastrointestinal Motility
2003;9(1):6-11
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: Itopride is a newly developed prokinetic agent enhancing gastric motility through both antidopaminergic and anti-acetylcholinesterase actions. The importance of esophageal motor dysfunction in the pathogenesis of gastro-esophageal reflux disease (GERD) makes it interesting to examine the effect of itopride on esophageal acid exposure. METHODS: The effect of itopride on esophageal 24-hour acid reflux variables was studied in 26 patients with GERD symptoms, pre-entry total acid exposure time (pH<4) of more than 5% and mild esophagitis (Savary-Miller grade I, II) by endoscopy. Ambulatory 24-hour pH monitoring and symptom assessment were performed after treatment with itopride 50 mg or 100 mg t.i.d for 4 weeks by a randomization allocation schedule with an open label. RESULTS: In both itopride groups, total symptom scores were decreased after treatment significantly. Itopride 300 mg was significantly more effective than 150 mg in decreasing the total time and total percent time of intraesophageal pH below 4, and DeMeester score. Consequently, no serious adverse effects were reported after administration in both groups. CONCLUSIONS: Itopride 100 mg t.i.d is effective to decrease pathologic reflux in patients with GERD. Therefore, it has a therapeutic potential for this diseases.
