A Case of Valproic Acid Induced DRESS Syndrome.
- Author:
Yoon Hwan KIM
1
;
Chong Won CHOI
;
Ga Young LEE
;
Won Serk KIM
Author Information
1. Department of Dermatology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. mdcwc@naver.com
- Publication Type:Case Report
- Keywords:
DRESS syndrome;
Valproic acid
- MeSH:
Anticonvulsants;
Drug Eruptions;
Eosinophilia;
Exanthema;
Fever;
Humans;
Leukocytosis;
Liver;
Lymphatic Diseases;
Lymphocytosis;
Middle Aged;
Phenobarbital;
Sulfonamides;
Valproic Acid
- From:Korean Journal of Dermatology
2012;50(1):85-88
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
DRESS syndrome is an uncommon but potentially life-threatening subset of severe drug eruption characterized by fever, rash, leukocytosis with eosinophilia or atypical lymphocytosis, lymphadenopathy, and liver or renal dysfunction. The aromatic anticonvulsants (phenytoin, phenobarbital, carbamazepine) and sulfonamides are the most common cause of DRESS syndrome. Valproic acid, which is a widely used non-aromatic anticonvulsant, rarely causes DRESS syndrome. We report a case of DRESS syndrome in 47-year-old man caused by the use of valproic acid.
