Clinical effects of botulinum toxin A intradermal injection in treatment of erythematotelangiectatic rosacea
10.3760/cma.j.issn.1671-0290.2022.04.011
- VernacularTitle:A型肉毒毒素皮内注射治疗红斑毛细血管扩张型玫瑰痤疮的效果
- Author:
Yangzi TIAN
1
;
Rongli ZHANG
;
Qian ZHANG
;
Huan JING
;
Lin GAO
;
Kai LI
Author Information
1. 第四军医大学西京皮肤医院皮肤科，西安 710032
- Keywords:
Rosacea;
Botulinum toxins, type A;
Comparative effectiveness research;
Intradermal injection;
Concentration
- From:
Chinese Journal of Medical Aesthetics and Cosmetology
2022;28(4):296-299
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of intradermal injection of botulinum toxin A (BTX-A) in the treatment of erythematotelangiectatic rosacea.Methods:From January 2019 to December 2020, 30 patients with erythematotelangiectatic rosacea were treated in the Department of Dermatology at Xijing Hospital, Fourth Military Medical University. There were 26 females and 4 males, the age range from 23 to 42 years, with the average (30.9±5.7) years. Patients were randomly divided into two groups and given intradermal injection of botulinum toxin A. In detail, 0.25 U and 0.5 U was injected at each point in the low and high concentration group of BTX-A. The clinician erythema assessment (CEA) scores were recorded before treatment and at 2, 4, 8 and 12 weeks after treatment. The standard grading system scores for rosacea were recorded before treatment and at 12 weeks after treatment.Results:Both treatments could significantly reduce CEA scores, but the declined degree was more significant ( P<0.05), the onset time was shorter and the duration of efficacy was longer in the high concentration group. The scores of flushing, persistent erythema, burning sensation, stinging sensation and the total score of the standard grading system for rosacea after treatment in both two groups were significantly lower than those before treatment (high concentration group: t=5.00, 5.93, 4.10, 2.74, 12.37; low concentration group: t=6.17, 4.12, 2.87, 2.81, 7.88; P<0.05), and the improvement in high concentration group was significantly more than that in low concentration group ( t=2.02, 2.31, 2.15, 2.56, P<0.05). There was no significant difference in the overall effective rate between the two treatments ( P>0.05). Conclusions:Intradermal injection of BTX-A is safe and effective in the treatment of rosacea. Compared with the low concentration group, the efficacy is better, the onset time is shorter and the duration of efficacy is longer in the high concentration group.
