The application value and research progress of urine free DNA in tumor molecular diagnosis
10.3760/cma.j.cn114452-20220211-00062
- VernacularTitle:尿液游离DNA在肿瘤分子诊断中的应用价值及研究进展
- Author:
Xiaodong REN
1
;
Ning SU
;
Xian′ge SUN
;
Wenman LI
;
Kun WEI
;
Qing HUANG
Author Information
1. 陆军特色医学中心检验科，重庆 400042
- Keywords:
Tumor;
Liquid biopsy;
Urine cell-free DNA;
Molecular diagnosis;
Biomarker
- From:
Chinese Journal of Laboratory Medicine
2022;45(12):1293-1296
- CountryChina
- Language:Chinese
-
Abstract:
Urine cell-free DNA (ucfDNA) contains DNA fragments released from the lysis of cells in the urinary system, and circulating cell-free DNA (ccfDNA) can also enter the urine after glomerular filtration, and the mutation information carried by tumor DNA contained in ucfDNA and ccfDNA is consistent. Therefore, as a biomarker for molecular diagnosis of urological and non-urinary tumors, ucfDNA, has become a research hotspot in the field of liquid biopsy in recent years. UcfDNA has potential application value in individualized treatment, early diagnosis, dynamic monitoring of therapeutic efficacy, and prognosis assessment, etc. However, in order to realize the clinical application of urine ucfDNA, the extraction and accurate detection of ucfDNA still need to be solved.
