Current status and prospect of biomarker research for schizophrenia
- VernacularTitle:精神分裂症生物标志物研究的现状与展望
- Author:
Mengyuan ZHU
1
;
Qing CHEN
;
Dan LI
;
Mengxia WANG
;
Renyu WANG
;
Yuxin ZHU
;
Weifeng JIN
;
Shuzi CHEN
;
Ping LI
;
Zhenhua LI
;
Peijun MA
;
Shuai LIU
;
Qiong GAO
;
Xiaoyan LOU
;
Jie XU
;
Lili ZHU
;
Ling ZHAO
;
Kangyi LIANG
;
Jinghong CHEN
;
Xunjia CHENG
;
Ke DONG
;
Xiaokui GUO
;
Qingtian LI
;
Yun SHI
;
Junyu SUN
;
Huabin XU
;
Ping LIN
Author Information
- Keywords: Schizophrenia; Laboratory testing; Genetic markers; Neurotransmitter; Intestinal flora
- From: Chinese Journal of Laboratory Medicine 2022;45(11):1191-1196
- CountryChina
- Language:Chinese
- Abstract: Schizophrenia is a serious mental disease. The diagnosis of schizophrenia so far relies heavily on subjective evidence, including self-reported experiences by patients, manifestations described by relatives, and abnormal behaviors assessed by psychiatrists. The diagnosis, monitoring of the disease progression and therapy efficacy assessment are challenging due to the lack of established laboratory biomarkers. Based on the current literature, clinical consensus, guidelines, and expert recommendations, this review highlighted evidence-based potential laboratory biomarkers for the diagnosis of schizophrenia, including genetic biomarkers, neurotransmitters, neurodevelopmental-related proteins, and intestinal flora, and discussed the potential future directions for the application of these biomarkers in this field, aiming to provide an objective basis for the use of these biomarkers in the early and accurate diagnosis, treatment, and prognosis and rehabilitation assessment of schizophrenia.
