The research progress of tissue factor pathway inhibitor
10.3760/cma.j.cn114452-20220411-00212
- VernacularTitle:组织因子途径抑制物的研究进展
- Author:
Xiangyu CAO
1
;
Jun WU
Author Information
1. 北京积水潭医院检验科，北京 100035
- Keywords:
Tissue factor pathway inhibitor;
Anticoagulation;
Detection method;
Coagulation disorders
- From:
Chinese Journal of Laboratory Medicine
2022;45(10):1005-1009
- CountryChina
- Language:Chinese
-
Abstract:
Tissue factor pathway inhibitor (TFPI) is a major inhibitor of tissue factor-mediated extrinsic coagulation pathway, mainly derived from microvascular endothelial cells. Recent studies have found that TFPI plays a role in hemophilia, sepsis, antiphospholipid syndrome, venous thromboembolism and other diseases, and participates in the occurrence and development of diseases through anticoagulation mechanism. At present, there are many methods to detect the source, content and function of TFPI, which are helpful for the diagnosis and treatment of clinical diseases.
