A case of hemolytic disease of the newborn caused by IgG anti-E
10.3760/cma.j.cn114452-20220214-00068
- VernacularTitle:IgG抗-E抗体引起的新生儿溶血病1例
- Author:
Anliu TANG
1
;
Songlin HU
;
Lijuan LIU
;
Ying WU
;
Yawen YANG
;
Lin WANG
Author Information
1. 解放军联勤保障部队第九二四医院输医学血科，桂林 541002
- Keywords:
Hemolysis;
Immunoglobulin G;
Prenatal diagnosis;
Antibody
- From:
Chinese Journal of Laboratory Medicine
2022;45(9):980-982
- CountryChina
- Language:Chinese
-
Abstract:
A case of hemolytic disease of the newborn (HDFN) caused by immunoglobulin (Ig) G anti-E was analyzed in this study. The ABO and Rh blood group of the newborn was O and CcDEe, respectively. The ABO and Rh blood group of her mother was A and CCDee, respectively. Thus, the reason of ABO and RhD hemolysis were impossible. The incompatible antibodies were found in the newborn serum by three serological tests. The antibody screening and identification test using the plasma and the red blood cell eluate from the newborn and the plasma from her mother showed that the HDFN was caused by the IgG anti-E antibodies. The case was caused by failing to prenatal screening for irregular antibodies. Therefore, the prenatal screening for irregular antibodies seems necessary for pregnant women to prevent, diagnose or manage the HDFN at an early time, reducing the occurrence of perinatal complications.
