Pediatric reference intervals for plasma and whole blood procalcitonin of in China: a multicenter research
10.3760/cma.j.cn114452-20220221-00085
- VernacularTitle:3天至6岁中国儿童外周血降钙素原生物参考区间建立
- Author:
Zhan MA
1
;
Fangzhen WU
;
Jiangtao MA
;
Yunsheng CHEN
;
Guixia LI
;
Jinbo LIU
;
Hongbing CHEN
;
Huiming YE
;
Xingyan BIAN
;
Dapeng CHEN
;
Jiangwei KE
;
Haiou YANG
;
Lijuan MA
;
Qiuhui PAN
;
Hongquan LUO
;
Xushan CAI
;
Yun XIE
;
Wenqi SONG
;
Lei ZHANG
;
Hong ZHANG
Author Information
1. 上海市儿童医院，上海交通大学医学院附属儿童医院检验科，上海200062
- Keywords:
Reference value;
Procalcitonin;
Child;
Blood
- From:
Chinese Journal of Laboratory Medicine
2022;45(6):581-588
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the biology reference interval (RI) of peripheral blood procalcitonin (PCT) for children between 3 days and 6 years old in China.Methods:Totally 3 353 reference individuals with apparent health or no specific diseases were recruited in 18 hospitals throughout the country during October 2020 to May 2021. Reference individuals were divided into four groups: 3-28 days, 29 days - 1 year, 1-3 years and 4-6 years. Vein blood or capillary blood were collected by percutaneous puncture from every reference individual. The PCT level in serum and the capillary whole blood were assayed by Roche Cobas e601 and Norman NRM411-S7 immunoanalyzer. Outliers were deleted and 95th percentiles of every group were provided as RIs. Man-Whitney U test or Kruskal-Wallis test were used performed to assess the difference among different gender, age or method groups. Results:The difference of PCT distribution between male and female is not statistically significant, but the difference between serum and capillary whole blood is statistically significant. The differences between age groups are significant too. For Roche e601, serum PCT RI of 3-28 days group is <0.23 μg/L, 29 days - 6 years are <0.11 μg/L. For NRM411, Serum PCT RI of 3-28 days group is <0.21 μg/L, 29 days - 1 year: <0.09 μg/L, 1 - 6 years: <0.10 μg/L. For whole blood PCT, RI of 3-28 days group is <0.26 μg/L, 29 days - 6 years is <0.15 μg/L.Conclusions:Serum and capillary whole blood PCT have different RIs, however, capillary whole blood PCT testing is valuable in pediatric application. Children in 3-28 days show higher PCT levels than other age group. To establish the RIs and understand the differences among different groups are essential for the interpretation and clinical application of peripheral blood PCT testing results.
