Current status and future considerations on laboratory diagnosis of viral central nervous system infections in children
10.3760/cma.j.cn114452-20220209-00058
- VernacularTitle:儿童中枢神经系统病毒感染实验室诊断的现状与思考
- Author:
Jin XU
1
;
Xunhua ZHU
Author Information
1. 复旦大学附属儿科医院临床检验医学中心，上海201102
- Keywords:
Central nervous system viral diseases;
Molecular diagnostic techniques;
Polymerase chain reaction;
Point-of-care testing;
High-throughput nucleotide seque
- From:
Chinese Journal of Laboratory Medicine
2022;45(6):563-567
- CountryChina
- Language:Chinese
-
Abstract:
Viral central nervous system infection (VCNSI), with high disability and mortality rates, is a serious threat for the health of children. Given the low pathogen load in cerebrospinal fluid and limitations of conventional virus detection technology, the early pathogenic diagnosis methods are less than ideal. With the development of multiplex polymerase chain reaction (PCR), digital PCR, point-of-care testing detection of nucleic acid, and metagenome high-throughput sequencing, the clinical use of viral diagnostic technologies has become more prevalent. In this comment, the current status and future directions of laboratory diagnosis of VCNSI in children are discussed.
