Macular vessel defects for Coats' disease associated with subfoveal fibrotic nodule
10.3760/cma.j.cn511434-20220520-00311
- VernacularTitle:Coats病伴中心凹下纤维结节患眼的黄斑微血管异常观察
- Author:
Juan ZHANG
1
;
Lu RUAN
;
Chen JIANG
;
Qian YANG
;
Yuqiao JU
;
Qing CHANG
;
Xin HUANG
Author Information
1. 复旦大学附属眼耳鼻喉科医院眼科, 上海 200030
- Keywords:
Retinal telangiectasis;
Subfoveal fibrotic nodule;
Macular vessel defects;
Tomography, optical coherence;
Regional blood flow
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(11):880-884
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate macular microvascular abnormalities in eyes with subfoveal fibrotic nodules secondary to Coats' disease.Methods:A cross-sectional study. From January 1, 2018 to July 30, 2021, 45 eyes of 45 patients diagnosed with Coats' disease with or without subfoveal fibrotic nodules in Eye and ENT Hospital, Shanghai Medical College of Fudan University were included in this study. There were 40 eyes in 40 males and 5 eyes in 5 females. All were under 21 years old. According to the presence or absence of subfoveal fiber nodules, the patients were divided into fibrotic group (26 cases, 26 eyes) and non-fibrotic group (19 cases, 19 eyes). Optical coherence tomography angiography was used to scan 3 mm×3 mm or 6 mm×6 mm macular area of both eyes. The software of the device automatically processed the images. The presence of FAZ edge anastomotic vascular arch ring breakage and abnormal microvascular branch (AMB) in the foveal avascular zone (FAZ) were observed.Results:In 26 eyes of fibrosis group, AMB originating from the parafoveal retinal capillary network was observed, which grew into and destroyed the integrity of the vascular arch ring at the edge of FAZ. AMB was crisscrossing and winding, and its curvature expands. B-scan images showed the blood flow signal in the subfoveal fiber nodule, and the blood flow signal traversed between the inner retina and the fiber nodule in 23 eyes (88.46%, 23/26). In the non-fibrosis group, all the vascular abnormalities were characterized by capillary dilation and defect, and no breakage of FAZ anastomotic vascular arch ring or AMB was observed.Conclusions:In Coats' disease with subfoveal fiber nodules, staggered and dilated AMBs emerge from the parafoveal vascular network, grow into and destroy the integrity of the vascular arch ring at the edge of FAZ, and grow down longitudinally into the fiber nodules.
