Research progress of Müller cell and macular hole
10.3760/cma.j.cn511434-20210319-00148
- VernacularTitle:Müller细胞与黄斑裂孔研究现状与进展
- Author:
Yiji PAN
1
;
Tao HE
Author Information
1. 武汉大学人民医院眼科中心，武汉 430000
- Keywords:
Müller cell;
Macular hole;
Review
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(10):862-866
- CountryChina
- Language:Chinese
-
Abstract:
Müller cells are glial cells of the retina, whose major processes cross the internal and external limiting membranes of the retina, maintaining the function and metabolism of retinal photoreceptors and neurons. Their structure and function are closely related to the development of macular hole (MH). Müller cells are involved in the formation and recovery of MH from the aspect of traction and protein, and their morphology and biological function also influence the regression of MH. The current treatment modality for MH is vitrectomy combined with internal limiting membrane (ILM) peeling, in which Müller cells play a dual role after ILM peeling in different stages of MH. And its potential to re-acquire a progenitor-like state following retinal injury with the ability to proliferate and generate new neurons making it a current research hot topic, which can be a reference and inspiration for clinical treatment.
