Gagtric Adenocarcinoma with Choriocarcinomatous and Hepatoid Differentiation: Report of a case.
- Author:
Kyeong Cheon JUNG
;
Woo Ho KIM
;
Yong Il KIM
;
Kook Jin CHOE
- Publication Type:Case Report
- Keywords:
Stomach;
Hepatoid'adenocarcinoma;
Choriocarcinoma;
Retrodifferentiation
- MeSH:
Adenocarcinoma
- From:Korean Journal of Pathology
1994;28(4):409-413
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Association of the hepatoid and choriocarcinomatous components in adenocarcinoma of the stomach is extremely unusual and raises a possibility of new approach understand the histogenesis of gastric hepatoid adenocarcinoma. This paper describes a Borrmann type III adenocarcinoma of the stomach with both choriocarcinomatous and hepatoid components in composite tumor pattern in a 50-year-old man. Tubular arrangement of differentiated embryonalcarcinoma was encountered in choricarcinomatous and hepatoid areas, which showed strong immunoreactivity to beta-HCG and AFP, respectively. The findings suggest that gastric adenocarcinoma may have a potential of differentiation toward embryonal carcinoma. from which both choriocarcinoma and hepatoid variant of gastric adenocarcinoma may develop by retrodifferentiation.
