Comparison of the thickness of macular ganglion cell inner plexiform layer in patients with a history of laser photocoagulation versus intravitreal injection of ranibizumab for retinopathy of prematurity
10.3760/cma.j.cn511434-20220509-00282
- VernacularTitle:早产儿视网膜病变激光光凝和雷珠单抗治疗史患儿黄斑区神经节细胞-内丛状层厚度比较
- Author:
Ya TIAN
1
;
Xinyu ZHAO
;
Miaohong CHEN
;
Zixin FAN
;
Xianlu ZENG
;
Lei ZHENG
;
Honghui HE
;
Jian ZENG
;
Shaochong ZHANG
;
Guoming ZHANG
Author Information
1. 深圳市眼科医院 暨南大学附属深圳眼科医院 深圳市眼病防治研究所，深圳 518040
- Keywords:
Retinopathy of prematurity;
Laser coagulation;
Angiogenesis inhibitors;
Tomography, optical coherence;
Ganglion cell inner plexiform layer thickness
- From:
Chinese Journal of Ocular Fundus Diseases
2022;38(7):551-555
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the thickness of the macular ganglion cell inner plexiform layer (mGCIPL) in patients with a history of laser photocoagulation (LP) versus intravitreal injection of ranibizumab (IVR) for retinopathy of prematurity (ROP).Methods:A retrospective clinical study. From June 2020 to January 2021, 70 eyes of 35 children with a history of surgery for ROP in Shenzhen Eye Hospital were included in the study. Among them, 18 males had 36 eyes, and 17 females had 34 eyes. The average age was 5.54±1.04 years. There were 18 patients (36 eyes) in LP group and 17 patients (34 eyes) in IVR group. There was no significant difference in age ( t=-1.956), sexual composition ratio ( χ2=0.030), birth gestational age ( t=-1.316) and birth weight ( t=-1.060) between the two groups ( P=0.059, 0.862, 0.197, 0.297). All the eyes underwent the examination of optical coherence tomography (OCT). An elliptical region of 14.13 mm 2 centered on macular fovea was scanned according to the macular cube 512×128 model of the Cirrus HD-OCT 5000. The software was used to automatically divide macular fovea into six sectors (superior, inferior, temporal-superior, temporal-inferior, nasal-superior and nasal-inferior) and the average and minimum thickness of mGCIPL. t test was used to compared mGCIPL thickness between two groups using independent samples. Pearson correlation analysis was used to evaluate the correlation between mGCIPL thickness and age, birth gestational age, birth weight. Results:Patients in IVR group had significantly decreased mGCIPL thickness than that in LP group in the six sectors (superior, inferior, temporal-superior, temporal-inferior, nasal-superior and nasal-inferior) and the average and minimum ( t=6.484, 6.719, 7.682, 7.697, 5.151, 5.008, 7.148, 6.581; P<0.05). The thickness of mGCIPL was not significantly correlated with age, birth gestational age, birth weight ( P>0.05). Conclusion:The thickness of mGCIPL in patients with IVR treatment history is thinner than that in LP treatment.
