The advances of microRNA in aortic aneurysms
10.3760/cma.j.cn112434-20210416-00140
- VernacularTitle:microRNA在主动脉瘤中的研究进展
- Author:
Congcong LUO
1
;
Yongliang ZHONG
;
Cheng LUO
;
Rutao GUO
;
Yipeng GE
;
Junming ZHU
Author Information
1. 首都医科大学附属北京安贞医院心血管外科，北京 100029
- From:
Chinese Journal of Thoracic and Cardiovascular Surgery
2022;38(6):371-375
- CountryChina
- Language:Chinese
-
Abstract:
Aortic aneurysm (AA) is a vascular disease involving the progressive dilation of aorta diameter. It is usually asymptomatic but with high mortality once rupture. Currently, there is no effective pharmacologic treatment. MicroRNA specifically refers to non-coding small RNAs consisting of 19-25 nucleotides. The characteristic of microRNA targeting multiple genes seems to form a complicated regulation network, which receives considerable attention. Emerging studies show that microRNAs are closely related to the occurrence and development of AA. Many microRNAs are involved in multiple cell processes and functions and may participate in the pathogenesis of AA, including endothelial cell dysfunction, inflammatory cell infiltration, smooth muscle cell apoptosis, and extracellular matrix degradation. This article will describe the animal models for AA research and the latest progression of microRNA and AA.
