Research progress in promotion of peripheral nerve regeneration by regulating macrophages
10.3760/cma.j.cn441206-20220224-00039
- VernacularTitle:调控巨噬细胞促进周围神经再生的研究进展
- Author:
Jianguo SONG
1
;
Haodong LIN
Author Information
1. 上海交通大学附属第一人民医院创伤中心，上海 200240
- Keywords:
Peripheral nerve injury;
Macrophages;
Cell polarization;
Endocytosis;
Phenotypic regulation
- From:
Chinese Journal of Microsurgery
2022;45(5):593-597
- CountryChina
- Language:Chinese
-
Abstract:
This article reviews the research progress in promotion of peripheral nerve regeneration by regulating macrophages, a new idea for the research and treatment of peripheral nerve injury. The Trauma Center of The First People's Hospital Affiliated to Shanghai Jiao Tong University reviewed the relevant literatures in the regulation of macrophages on peripheral nerve regeneration at home and abroad, from 2013 to 2021, were reviewed and analysed. Of the study from 2013 to 2021, autologous nerve transfer was the main option in the treatment of peripheral nerve injury, but it has many setbacks such as insufficient donor, new nerve injury and local neuroma. Modulating macrophage-related function can effectively improve the prognosis of nerve injury. In recent years, the regulation of macrophages in the treatment of nerve injury is mainly through the mechanism of M1 macrophages polarisation to M2 macrophages, increase of phagocytosis, change of the phenotype of macrophages, and so on. By studying the characteristics of macrophages and regulating the function and phenotype of macrophages, it would provide a new idea and important research direction in the treatment of peripheral nerve injury.
