Evaluation of Kyoto gastritis score for Helicobacter pylori infection under gastroscopy
10.3760/cma.j.cn321463-20210712-00436
- VernacularTitle:基于京都胃炎评分判断胃镜下幽门螺杆菌感染状态的研究
- Author:
Mengjiao ZHANG
1
;
Lianlian WU
;
Ming XU
;
Honggang YU
Author Information
1. 武汉大学人民医院消化内科 消化系统疾病湖北省重点实验室 湖北省消化疾病微创 诊治医学临床研究中心，武汉 430060
- Keywords:
Helicobacter pylori;
Gastroscopy;
Kyoto gastritis score;
Mucosal manifestations
- From:
Chinese Journal of Digestive Endoscopy
2022;39(9):707-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the Kyoto gastritis score for diagnosing Helicobacter pylori ( HP) infection in Chinese people. Methods:A total of 902 cases who underwent 13C-urea breath test and gastroscopy at the same time at the Digestive Endoscopy center of Renmin Hospital of Wuhan University from January 2020 to December 2020 were studied retrospectively, including 345 cases of HP-positive and 557 of HP-negative. The differences of mucosal features and Kyoto gastritis score between HP-positive and HP-negative patients were analyzed. A receiver operating characteristic curve was plotted to predict HP infection by Kyoto gastritis score. Results:Compared with HP-negative patients, nodules [8.1% (28/345) VS 0.2% (1/557), χ2=86.29, P<0.001], diffuse redness [47.8% (165/345) VS 6.6% (37/557), χ2=413.63, P<0.001], atrophy [27.8% (96/345) VS 13.8% (77/557), χ2=52.90, P<0.001] and fold enlargement [69.0% (238/345) VS 36.6% (204/557), χ2=175.38, P<0.001] occurred more frequently in HP-positive patients. For predicting HP infection, nodules showed the highest specificity [99.8% (556/557)] and positive predictive value [96.6% (28/29)], diffuse redness showed the largest area under the receiver operating characteristic curve (AUC) of 0.707, and fold enlargement showed the highest sensitivity [69.0% (238/345)] and negative predictive value [76.7% (353/460)]. The Kyoto gastritis score of HP-positive patients was higher than that of HP-negative patients [2 (1, 2) VS 0 (0, 1), Z=20.82, P<0.001]. Furthermore, at an optimal threshold of 2, the AUC of the Kyoto gastritis score for predicting HP infection was 0.779. Conclusion:Nodules, diffuse redness, atrophy and fold enlargement under gastroscopy can suggest positive of HP infection, and the Kyoto gastritis score≥2 is sufficient reference to diagnose HP positive.
