Endoscopic submucosal dissection for early hypopharyngeal carcinoma and precancerous lesions
10.3760/cma.j.cn321463-20210115-00042
- VernacularTitle:早期下咽癌及其癌前病变内镜黏膜下剥离术治疗价值
- Author:
Yu GONG
1
;
Yueming ZHANG
;
Jiqing ZHU
;
Shun HE
;
Lizhou DOU
;
Yong LIU
;
Yan KE
;
Xudong LIU
;
Yumeng LIU
;
Hairui WU
;
Ying LYU
;
Guiqi WANG
Author Information
1. 国家癌症中心 中国医学科学院北京协和医学院肿瘤医院内镜科，北京 100021
- Keywords:
Hypopharyngeal neoplasms;
Early-stage cancer;
Precancerous lesions;
Endoscopic submucosal dissection
- From:
Chinese Journal of Digestive Endoscopy
2022;39(9):691-694
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the efficacy and safety of endoscopic submucosal dissection (ESD) for early hypopharyngeal carcinoma and precancerous lesions.Methods:Clinical data of 41 patients who received ESD for early hypopharyngeal carcinoma and precancerous lesions from August 2013 to August 2019 in the Department of Endoscopy of Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College were retrospectively analyzed. Main outcome measurements included operation completion rate, operation time, en bloc resection rate, R0 resection rate, complication rate and recurrence.Results:ESD was successfully completed in all 41 cases, with a success rate of 100.0% and a mean time of 49.1 min (ranged 10-110 min). Fifty-four lesions underwent en bloc resection, with an en bloc resection rate of 98.2% (54/55), of which 41 had negative horizontal and vertical margins, and the R0 resection rate was 74.5% (41/55). During the operation of 55 lesions, there was a small amount of blood oozing on the wound surface, and electrocoagulation with thermal biopsy forceps could successfully stop the bleeding. No perforation occurred, and 2 cases (4.3%) had delayed bleeding after ESD, and hemostasis was successful under emergency endoscopy. Postoperative endoscopy showed that 1 case (2.2%) had esophageal entrance stenosis, and the obstruction was relieved after repeated water balloon dilatation. The follow-up period ranged from 3 to 72 months, and the median time was 18 months. One case was found to have mucosal lesions in the same part of the hypopharynx and received ESD treatment again. Follow-up to October 2020, no residual lesions and recurrence were found.Conclusion:ESD is a safe and effective option for the treatment of early hypopharyngeal carcinoma and precancerous lesions, which is worthy of clinical application.
