Evaluation of polysaccharide hemostatic system for arterial hemorrhage of upper digestive tract
10.3760/cma.j.cn321463-20200330-00113
- VernacularTitle:多聚糖术中止血装置用于上消化道动脉性出血的动物实验研究
- Author:
Yibin SUN
1
;
Chen CHEN
;
Yujia XIONG
;
Chenhuan TAN
;
Yiting LIU
;
Ji FENG
;
Yifan MA
;
Dongtao SHI
;
Deqing ZHANG
;
Ling LI
;
Rui LI
Author Information
1. 苏州大学附属第一医院消化内科，苏州 215006
- Keywords:
Gastrointestinal hemorrhage;
Hemostasis, endoscopic;
Efficiency;
Safety;
Polysaccharide hemostatic system
- From:
Chinese Journal of Digestive Endoscopy
2022;39(7):559-563
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the efficacy and safety of EndoClot polysaccharide hemostatic system (EndoClot PHS) for heparinized arterial hemorrhage of upper digestive tract (Forrest Ⅰa) in animal model.Methods:Twelve experimental pigs were randomly divided into the test group ( n=6) and the control group ( n=6) by simple random grouping method. Gastric arterial hemorrhage models were established. Endoclot PHS and Hemospray were used to spray on the wound to stop bleeding in the test group and the control group respectively. The time of effective hemostasis, the amount of hemostatic particles used, and the blockage of the powder feeding tube and its replacement were compared between the two groups. The survival and complications of experimental pigs were observed after the operation. In 10 days after the operation, the experimental pigs were euthanized for pathological dissection. Results:Spurting or pulsatile bleeding was achieved in all experimental pigs. There were significant differences in the time of effective hemostasis (8.75±0.84 min VS 9.83±0.62 min, t=-2.53, P=0.030) and the amount of hemostatic particles used to achieve effective hemostasis (6.71±0.39 g VS 14.10±1.62 g, t=-10.86, P<0.001) between the test group and the control group. There was no significant difference in the occurence of clogging or the replacement of powder feeding pipes between the two groups (0.64±0.02 times VS 0.67±0.04 times, t=-1.64, P=0.131). In addition, the gas source of the test group was stable, and the visual field under the endoscope was clear. Neither the test group nor the control group had gastric lesions, perforation, or embolism. The blood glucose, blood routine, and liver and kidney functions were normal, and no thrombosis or embolism of the main organs occurred in either group. Conclusion:EndoClot PHS is safe and effective for heparinized upper gastrointestinal arterial hemorrhage (Forrest Ⅰa) in animal models.
